Isavuconazole Pharmacodynamic Target Determination for Candida Species in anIn VivoMurine Disseminated Candidiasis Model

Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model.

Pharmacodynamic (PD) studies with triazoles in the neutropenic murine disseminated candidiasis model have been performed extensively for Candida albicans. They have consistently shown that the pharmacodynamic index most closely correlated with efficacy is the ratio of the 24-h area under the concentration-time curve (AUC) to the MIC, and a target 24-h free-drug AUC/MIC ratio near 25 is associat...

Isavuconazole (BAL4815) Pharmacodynamic Target Determination in an in vivo

にば Invasive pulmonary aspergillosis (IPA) continues to rise in concert with increasing にぱ numbers of immune suppression techniques to treat other medical conditions and にひ transplantation. Despite these advances, morbidity and mortality remain unacceptably ぬど high. One strategy utilized to optimize outcomes is antifungal pharmacodynamic (PD) ぬな examination. We explored the pharmacodynamics of a...

In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model.

Previous studies using in vivo candidiasis models have demonstrated that the concentration-associated pharmacodynamic indices, the maximum concentration of a drug in serum/MIC and 24-h area under the curve (AUC)/MIC, are associated with echinocandin treatment efficacy. The current investigations used a neutropenic murine model of disseminated Candida albicans and C. glabrata infection to identi...

Target Determination for Candida species in an In vivo 1

Detection of Candida antigenuria in disseminated candidiasis by immunoblotting.

Immunoblotting (Western blotting) was used to detect Candida albicans antigens in urine of 10 patients with disseminated candidiasis who had two or more positive blood cultures. Twelve urine samples were examined; and antigenuria was found in five of six patients with C. albicans infections, in one patient with a mixed Candida infection (including C. albicans), and in one of two patients with C...